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This subtype of acutemyelocytic leukaemia (AML) is associated with productionof a fusion gene PML-RAR due to a specific chromosomaltranslocation. In a different I-SceI-based NHEJassay, expression of wild-type p53 inhibited NHEJ events that required trimming ofnoncomplementary overhangs from the DSB ends

In a different I-SceI-based NHEJassay, expression of wild-type p53 inhibited NHEJ events that required trimming ofnoncomplementary overhangs from the DSB ends.

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